A pro-inflammatory genotype predisposes to Barrett's esophagus

A pro-inflammatory genotype predisposes to Barrett's esophagus.

INTRODUCTION Severity of mucosal inflammation is shown to be associated with Barrett's esophagus (BE) development in animals. It has therefore been postulated that a strong pro-inflammatory host response predisposes to BE. AIM To determine the impact of cytokine gene polymorphisms on the development of BE. METHODS The multiplex SNaPshot method was used to determine interleukin (IL)-12B (A+1...

Inflammatory priming predisposes mice to age-related retinal degeneration.

Disruption of cellular processes affected by multiple genes and accumulation of numerous insults throughout life dictate the progression of age-related disorders, but their complex etiology is poorly understood. Postmitotic neurons, such as photoreceptor cells in the retina and epithelial cells in the adjacent retinal pigmented epithelium, are especially susceptible to cellular senescence, whic...

Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?

Inflammatory priming predisposes to age − related retinal degeneration in mice

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Cancer commonly occurs in the elderly and immunotherapy (IT) is being increasingly applied to this population. However, the majority of preclinical mouse tumor models assessing potential efficacy and toxicities of therapeutics use young mice. We assessed the impact of age on responses to systemic immune stimulation. In contrast to young mice, systemic cancer IT regimens or LPS given to aged mic...